SidaGhanaV1, Main, Exploration, bibRecord, 000C24

High Prevalence of Unique Recombinant Forms of HIV-1 in Ghana : Molecular Epidemiology From an Antiretroviral Resistance Study

Identifieur interne : 000C24 ( Main/Exploration ); précédent : 000C23; suivant : 000C25

High Prevalence of Unique Recombinant Forms of HIV-1 in Ghana : Molecular Epidemiology From an Antiretroviral Resistance Study

Auteurs : Elena Delgado [Espagne] ; William Kwabena Ampofo [Espagne] ; Maria Sierra [Espagne] ; Kwasi Torpey [Ghana] ; Lucia Perez-Alvarez [Espagne] ; Evelyn Yayra Bonney [Ghana] ; Ya Diul Mukadi [États-Unis] ; Margaret Lartey [Ghana] ; Charles Nyarko [Ghana] ; Richard Noamesi Amenyah [Ghana] ; Michael M. Thomson [Espagne] ; Rafael Ndjera [Espagne]

Source :

Journal of acquired immune deficiency syndromes : (1999) [ 1525-4135 ] ; 2008.

RBID : Pascal:08-0406807

Descripteurs français

KwdFr :
- Agents antiVIH (pharmacologie), Données de séquences moléculaires, Ghana (épidémiologie), Gènes pol, Humains, Infections à VIH (virologie), Infections à VIH (épidémiologie), Inhibiteurs de la transcriptase inverse (pharmacologie), Inhibiteurs de protéase du VIH (pharmacologie), Mutation, Phylogénie, Polymorphisme génétique, Prévalence, Recombinaison génétique, Résistance virale aux médicaments (génétique), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification), Épidémiologie moléculaire.
MESH :
- génétique : Résistance virale aux médicaments, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- isolement et purification : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- pharmacologie : Agents antiVIH, Inhibiteurs de la transcriptase inverse, Inhibiteurs de protéase du VIH.
- virologie : Infections à VIH.
- épidémiologie : Ghana, Infections à VIH.
Pascal (Inist)
- Données de séquences moléculaires, Gènes pol, Humains, Mutation, Phylogénie, Polymorphisme génétique, Prévalence, Recombinaison génétique, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Virus HIV1, Prévalence, Epidémiologie moléculaire, Ghana, Génotype, Antiviral, Antirétroviral, Résistance, Soustype, Microbiologie, Virologie, Épidémiologie moléculaire.
Wicri :
- geographic : Ghana.

English descriptors

KwdEn :
- Anti-HIV Agents (pharmacology), Antiretroviral agent, Antiviral, Drug Resistance, Viral (genetics), Genes, pol, Genotype, Ghana, Ghana (epidemiology), HIV Infections (epidemiology), HIV Infections (virology), HIV Protease Inhibitors (pharmacology), HIV-1 (classification), HIV-1 (drug effects), HIV-1 (genetics), HIV-1 (isolation & purification), HIV-1 virus, Humans, Microbiology, Molecular Epidemiology, Molecular Sequence Data, Molecular epidemiology, Mutation, Phylogeny, Polymorphism, Genetic, Prevalence, Recombination, Genetic, Resistance, Reverse Transcriptase Inhibitors (pharmacology), Subtype, Virology.
MESH :
- chemical , pharmacology : Anti-HIV Agents, HIV Protease Inhibitors, Reverse Transcriptase Inhibitors.
- geographic , epidemiology : Ghana.
- classification : HIV-1.
- drug effects : HIV-1.
- epidemiology : HIV Infections.
- genetics : Drug Resistance, Viral, HIV-1.
- isolation & purification : HIV-1.
- virology : HIV Infections.
- Genes, pol, Humans, Molecular Epidemiology, Molecular Sequence Data, Mutation, Phylogeny, Polymorphism, Genetic, Prevalence, Recombination, Genetic.

Abstract

Background: In Ghana, programs to expand antiretroviral access are being implemented. In this context, the dynamic genetic evolution of HIV-1 requires continuous surveillance, particularly when diverse genetic forms co-circulate. Methods: Phylogenetic and antiretroviral resistance analyses of HIV-1 partial pol sequences from plasma RNA samples from 207 Ghanaian individuals were performed. Results: 66% of infections were CRF02_AG, whereas 25% were unique recombinant forms (URFs). All 52 URFs were characterized by bootscanning. CRF02_AG was parental strain in 87% of URFs, forming recombinants with genetic forms circulating in minor proportions: CRF06_cpx, sub-subtype A3, CRF09_cpx and subtypes G and D. Two triple recombinants (CRF02_AG/A3/CRF06_cpx and CRF02_AG/A3/CRF09_cpx) were identified. Antiretroviral resistance analyses revealed that six individuals, five of which were antiretroviral drug-experienced, harbored mutations conferring high level of resistance to reverse transcriptase inhibitors. No major resistance mutations were identified in the protease, although insertions of one and three amino acids were detected. Conclusions: The high frequency of URFs detected probably reflects a significant incidence of coinfections or superinfections with diverse viral strains, which increases the genetic complexity of the HIV-1 epidemic in West Africa. Monitoring of HIV-1 drug resistance might provide data on the implications of intersubtype recombination in response to antiretrovirals.

Affiliations:

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">High Prevalence of Unique Recombinant Forms of HIV-1 in Ghana : Molecular Epidemiology From an Antiretroviral Resistance Study</title>
<author><name sortKey="Delgado, Elena" sort="Delgado, Elena" uniqKey="Delgado E" first="Elena" last="Delgado">Elena Delgado</name>
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<author><name sortKey="Kwabena Ampofo, William" sort="Kwabena Ampofo, William" uniqKey="Kwabena Ampofo W" first="William" last="Kwabena Ampofo">William Kwabena Ampofo</name>
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<author><name sortKey="Sierra, Maria" sort="Sierra, Maria" uniqKey="Sierra M" first="Maria" last="Sierra">Maria Sierra</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Viral Pathogenesis Department, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda</s1>
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<author><name sortKey="Torpey, Kwasi" sort="Torpey, Kwasi" uniqKey="Torpey K" first="Kwasi" last="Torpey">Kwasi Torpey</name>
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<author><name sortKey="Perez Alvarez, Lucia" sort="Perez Alvarez, Lucia" uniqKey="Perez Alvarez L" first="Lucia" last="Perez-Alvarez">Lucia Perez-Alvarez</name>
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<s2>Madrid</s2>
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<author><name sortKey="Yayra Bonney, Evelyn" sort="Yayra Bonney, Evelyn" uniqKey="Yayra Bonney E" first="Evelyn" last="Yayra Bonney">Evelyn Yayra Bonney</name>
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<placeName><region type="state">Virginie</region>
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<author><name sortKey="Nyarko, Charles" sort="Nyarko, Charles" uniqKey="Nyarko C" first="Charles" last="Nyarko">Charles Nyarko</name>
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<author><name sortKey="Noamesi Amenyah, Richard" sort="Noamesi Amenyah, Richard" uniqKey="Noamesi Amenyah R" first="Richard" last="Noamesi Amenyah">Richard Noamesi Amenyah</name>
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</placeName>
</affiliation>
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<author><name sortKey="Thomson, Michael M" sort="Thomson, Michael M" uniqKey="Thomson M" first="Michael M." last="Thomson">Michael M. Thomson</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Viral Pathogenesis Department, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda</s1>
<s2>Madrid</s2>
<s3>ESP</s3>
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<sZ>2 aut.</sZ>
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</inist:fA14>
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<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ndjera, Rafael" sort="Ndjera, Rafael" uniqKey="Ndjera R" first="Rafael" last="Ndjera">Rafael Ndjera</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Viral Pathogenesis Department, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda</s1>
<s2>Madrid</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of acquired immune deficiency syndromes : (1999)</title>
<title level="j" type="abbreviated">J. acquir. immune defic. syndr. : (1999)</title>
<idno type="ISSN">1525-4135</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of acquired immune deficiency syndromes : (1999)</title>
<title level="j" type="abbreviated">J. acquir. immune defic. syndr. : (1999)</title>
<idno type="ISSN">1525-4135</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-HIV Agents (pharmacology)</term>
<term>Antiretroviral agent</term>
<term>Antiviral</term>
<term>Drug Resistance, Viral (genetics)</term>
<term>Genes, pol</term>
<term>Genotype</term>
<term>Ghana</term>
<term>Ghana (epidemiology)</term>
<term>HIV Infections (epidemiology)</term>
<term>HIV Infections (virology)</term>
<term>HIV Protease Inhibitors (pharmacology)</term>
<term>HIV-1 (classification)</term>
<term>HIV-1 (drug effects)</term>
<term>HIV-1 (genetics)</term>
<term>HIV-1 (isolation & purification)</term>
<term>HIV-1 virus</term>
<term>Humans</term>
<term>Microbiology</term>
<term>Molecular Epidemiology</term>
<term>Molecular Sequence Data</term>
<term>Molecular epidemiology</term>
<term>Mutation</term>
<term>Phylogeny</term>
<term>Polymorphism, Genetic</term>
<term>Prevalence</term>
<term>Recombination, Genetic</term>
<term>Resistance</term>
<term>Reverse Transcriptase Inhibitors (pharmacology)</term>
<term>Subtype</term>
<term>Virology</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Agents antiVIH (pharmacologie)</term>
<term>Données de séquences moléculaires</term>
<term>Ghana (épidémiologie)</term>
<term>Gènes pol</term>
<term>Humains</term>
<term>Infections à VIH (virologie)</term>
<term>Infections à VIH (épidémiologie)</term>
<term>Inhibiteurs de la transcriptase inverse (pharmacologie)</term>
<term>Inhibiteurs de protéase du VIH (pharmacologie)</term>
<term>Mutation</term>
<term>Phylogénie</term>
<term>Polymorphisme génétique</term>
<term>Prévalence</term>
<term>Recombinaison génétique</term>
<term>Résistance virale aux médicaments (génétique)</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique)</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification)</term>
<term>Épidémiologie moléculaire</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-HIV Agents</term>
<term>HIV Protease Inhibitors</term>
<term>Reverse Transcriptase Inhibitors</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ghana</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>HIV-1</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HIV-1</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Drug Resistance, Viral</term>
<term>HIV-1</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Résistance virale aux médicaments</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>HIV-1</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agents antiVIH</term>
<term>Inhibiteurs de la transcriptase inverse</term>
<term>Inhibiteurs de protéase du VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Ghana</term>
<term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Genes, pol</term>
<term>Humans</term>
<term>Molecular Epidemiology</term>
<term>Molecular Sequence Data</term>
<term>Mutation</term>
<term>Phylogeny</term>
<term>Polymorphism, Genetic</term>
<term>Prevalence</term>
<term>Recombination, Genetic</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Données de séquences moléculaires</term>
<term>Gènes pol</term>
<term>Humains</term>
<term>Mutation</term>
<term>Phylogénie</term>
<term>Polymorphisme génétique</term>
<term>Prévalence</term>
<term>Recombinaison génétique</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
<term>Virus HIV1</term>
<term>Prévalence</term>
<term>Epidémiologie moléculaire</term>
<term>Ghana</term>
<term>Génotype</term>
<term>Antiviral</term>
<term>Antirétroviral</term>
<term>Résistance</term>
<term>Soustype</term>
<term>Microbiologie</term>
<term>Virologie</term>
<term>Épidémiologie moléculaire</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: In Ghana, programs to expand antiretroviral access are being implemented. In this context, the dynamic genetic evolution of HIV-1 requires continuous surveillance, particularly when diverse genetic forms co-circulate. Methods: Phylogenetic and antiretroviral resistance analyses of HIV-1 partial pol sequences from plasma RNA samples from 207 Ghanaian individuals were performed. Results: 66% of infections were CRF02_AG, whereas 25% were unique recombinant forms (URFs). All 52 URFs were characterized by bootscanning. CRF02_AG was parental strain in 87% of URFs, forming recombinants with genetic forms circulating in minor proportions: CRF06_cpx, sub-subtype A3, CRF09_cpx and subtypes G and D. Two triple recombinants (CRF02_AG/A3/CRF06_cpx and CRF02_AG/A3/CRF09_cpx) were identified. Antiretroviral resistance analyses revealed that six individuals, five of which were antiretroviral drug-experienced, harbored mutations conferring high level of resistance to reverse transcriptase inhibitors. No major resistance mutations were identified in the protease, although insertions of one and three amino acids were detected. Conclusions: The high frequency of URFs detected probably reflects a significant incidence of coinfections or superinfections with diverse viral strains, which increases the genetic complexity of the HIV-1 epidemic in West Africa. Monitoring of HIV-1 drug resistance might provide data on the implications of intersubtype recombination in response to antiretrovirals.</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
<li>Ghana</li>
<li>États-Unis</li>
</country>
<region><li>Communauté de Madrid</li>
<li>Région du Grand Accra</li>
<li>Virginie</li>
</region>
<settlement><li>Accra</li>
<li>Legon (Ghana)</li>
<li>Madrid</li>
</settlement>
<orgName><li>Université du Ghana</li>
</orgName>
</list>
<tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Delgado, Elena" sort="Delgado, Elena" uniqKey="Delgado E" first="Elena" last="Delgado">Elena Delgado</name>
</region>
<name sortKey="Kwabena Ampofo, William" sort="Kwabena Ampofo, William" uniqKey="Kwabena Ampofo W" first="William" last="Kwabena Ampofo">William Kwabena Ampofo</name>
<name sortKey="Ndjera, Rafael" sort="Ndjera, Rafael" uniqKey="Ndjera R" first="Rafael" last="Ndjera">Rafael Ndjera</name>
<name sortKey="Perez Alvarez, Lucia" sort="Perez Alvarez, Lucia" uniqKey="Perez Alvarez L" first="Lucia" last="Perez-Alvarez">Lucia Perez-Alvarez</name>
<name sortKey="Sierra, Maria" sort="Sierra, Maria" uniqKey="Sierra M" first="Maria" last="Sierra">Maria Sierra</name>
<name sortKey="Thomson, Michael M" sort="Thomson, Michael M" uniqKey="Thomson M" first="Michael M." last="Thomson">Michael M. Thomson</name>
</country>
<country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Torpey, Kwasi" sort="Torpey, Kwasi" uniqKey="Torpey K" first="Kwasi" last="Torpey">Kwasi Torpey</name>
</region>
<name sortKey="Lartey, Margaret" sort="Lartey, Margaret" uniqKey="Lartey M" first="Margaret" last="Lartey">Margaret Lartey</name>
<name sortKey="Noamesi Amenyah, Richard" sort="Noamesi Amenyah, Richard" uniqKey="Noamesi Amenyah R" first="Richard" last="Noamesi Amenyah">Richard Noamesi Amenyah</name>
<name sortKey="Nyarko, Charles" sort="Nyarko, Charles" uniqKey="Nyarko C" first="Charles" last="Nyarko">Charles Nyarko</name>
<name sortKey="Yayra Bonney, Evelyn" sort="Yayra Bonney, Evelyn" uniqKey="Yayra Bonney E" first="Evelyn" last="Yayra Bonney">Evelyn Yayra Bonney</name>
</country>
<country name="États-Unis"><region name="Virginie"><name sortKey="Mukadi, Ya Diul" sort="Mukadi, Ya Diul" uniqKey="Mukadi Y" first="Ya Diul" last="Mukadi">Ya Diul Mukadi</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Le SIDA au Ghana (serveur d'exploration)

High Prevalence of Unique Recombinant Forms of HIV-1 in Ghana : Molecular Epidemiology From an Antiretroviral Resistance Study

High Prevalence of Unique Recombinant Forms of HIV-1 in Ghana : Molecular Epidemiology From an Antiretroviral Resistance Study

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	Le SIDA au Ghana (serveur d'exploration)
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